About Importin subunit alpha-8
Importin subunit alpha-8 (KPNA7) is a protein
from Homo sapiens identified by UniProt accession
A9QM74, 516 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Importin subunit alpha-8 |
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| UniProt accession | A9QM74 |
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| Gene | KPNA7 |
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| Organism | Homo sapiens |
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| Length | 516 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- oocyte/zygote/embryo maturation arrest 17 · score 0.59
- influenza · score 0.46
- partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome · score 0.37
- Intellectual disability, mild · score 0.37
- eosinophil count · score 0.31
- eosinophil percentage of leukocytes · score 0.15
- body height · score 0.15
- mean corpuscular hemoglobin · score 0.15
- ulcerative colitis · score 0.10
- inflammatory bowel disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A9QM74-F1 | alphafold | PREDICTED | 85.77 | — |
Amino-acid sequence (516 residues)
MPTLDAPEER RRKFKYRGKD VSLRRQQRMA VSLELRKAKK DEQTLKRRNI TSFCPDTPSE KTAKGVAVSL TLGEIIKGVN SSDPVLCFQA TQTARKMLSQ EKNPPLKLVI EAGLIPRMVE FLKSSLYPCL QFEAAWALTN IASGTSEQTR AVVEGGAIQP LIELLSSSNV AVCEQAVWAL GNIAGDGPEF RDNVITSNAI PHLLALISPT LPITFLRNIT WTLSNLCRNK NPYPCDTAVK QILPALLHLL QHQDSEVLSD ACWALSYLTD GSNKRIGQVV NTGVLPRLVV LMTSSELNVL TPSLRTVGNI VTGTDEQTQM AIDAGMLNVL PQLLQHNKPS IQKEAAWALS NVAAGPCHHI QQLLAYDVLP PLVALLKNGE FKVQKEAVWM VANFATGATM DQLIQLVHSG VLEPLVNLLT APDVKIVLII LDVISCILQA AEKRSEKENL CLLIEELGGI DRIEALQLHE NRQIGQSALN IIEKHFGEEE DESQTLLSQV IDQDYEFIDY ECLAKK
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