About NUT family member 2E
NUT family member 2E (NUTM2E) is a protein
from Homo sapiens identified by UniProt accession
B1AL46, 878 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | NUT family member 2E |
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| UniProt accession | B1AL46 |
|---|
| Gene | NUTM2E |
|---|
| Organism | Homo sapiens |
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| Length | 878 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.11
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 3 · score 0.06
- spermatogenic failure 31 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B1AL46-F1 | alphafold | PREDICTED | 46.58 | — |
Amino-acid sequence (878 residues)
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST FPSTPLVTEQ DGCSPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK AQTACLPPPR PQRPVTKARR PPPQPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HSRAAPSRGT ARLDSSSSKF AAGQGAERDV PDPQEGVGME TCPPQTTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AARPTSPPQD HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK QPLFGSLSPA EKTPHRGPGL RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ
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