NALCN channel auxiliary factor 1 (NALF1)

About NALCN channel auxiliary factor 1

NALCN channel auxiliary factor 1 (NALF1) is a protein from Homo sapiens identified by UniProt accession B1AL88, 458 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.

Target properties

Protein name	NALCN channel auxiliary factor 1
UniProt accession	B1AL88
Gene	NALF1
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (107)

Diseases linked to this target (Open Targets).

diverticular disease · score 0.45
diverticulitis · score 0.42
mathematical ability · score 0.41
body mass index · score 0.38
protein measurement · score 0.33
sphingomyelin measurement · score 0.32
daytime rest measurement · score 0.31
body height · score 0.31
neurofibrillary tangles measurement · score 0.30
adolescent idiopathic scoliosis · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B1AL88-F1	alphafold	PREDICTED	61.21	—

Amino-acid sequence (458 residues)

MTRGAWMCRQ YDDGLKIWLA APRENEKPFI DSERAQKWRL SLASLLFFTV LLSDHLWFCA EAKLTRARDK EHQQQQRQQQ QQQQQQRQRQ QQQQQRRQQE PSWPALLASM GESSPAAQAH RLLSASSSPT LPPSPGDGGG GGGKGNRGKD DRGKALFLGN SAKPVWRLET CYPQGASSGQ CFTVENADAV CARNWSRGAA GGDGQEVRSK HPTPLWNLSD FYLSFCNSYT LWELFSGLSS PNTLNCSLDV VLKEGGEMTT CRQCVEAYQD YDHHAQEKYE EFESVLHKYL QSEEYSVKSC PEDCKIVYKA WLCSQYFEVT QFNCRKTIPC KQYCLEVQTR CPFILPDNDE VIYGGLSSFI CTGLYETFLT NDEPECCDVR REEKSNNPSK GTVEKSGSCH RTSLTVSSAT RLCNSRLKLC VLVLILLHTV LTASAAQNTA GLSFGGINTL EENSTNEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards