About Radial spoke head 10 homolog B2
Radial spoke head 10 homolog B2 (RSPH10B2) is a protein
from Homo sapiens identified by UniProt accession
B2RC85, 870 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Radial spoke head 10 homolog B2 |
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| UniProt accession | B2RC85 |
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| Gene | RSPH10B2 |
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| Organism | Homo sapiens |
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| Length | 870 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- APOE carrier status · score 0.18
- Alzheimer disease · score 0.18
- appendicular lean mass · score 0.08
- leukocyte count · score 0.08
- myeloid white cell count · score 0.06
- Myopia · score 0.05
- age at onset · score 0.05
- vital capacity · score 0.04
- mitochondrial heteroplasmy measurement · score 0.04
- refractive error · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B2RC85-F1 | alphafold | PREDICTED | 70.65 | — |
Amino-acid sequence (870 residues)
MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNTYVFFV NTLFHAYKRE EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV SSSHLILDPP KEDVTVSPSS KTITSKKKKK
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