About Complement C1q and tumor necrosis factor-related protein 9B
Complement C1q and tumor necrosis factor-related protein 9B (C1QTNF9B) is a protein
from Homo sapiens identified by UniProt accession
B2RNN3, 333 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Complement C1q and tumor necrosis factor-related protein 9B |
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| UniProt accession | B2RNN3 |
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| Gene | C1QTNF9B |
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| Organism | Homo sapiens |
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| Length | 333 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.29
- BMI-adjusted waist circumference · score 0.11
- pathological myopia · score 0.10
- bone density · score 0.07
- urate measurement · score 0.07
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- obesity due to pro-opiomelanocortin deficiency · score 0.06
- obesity due to prohormone convertase I deficiency · score 0.05
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
- LIPE-related familial partial lipodystrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B2RNN3-F1 | alphafold | PREDICTED | 64.62 | — |
Amino-acid sequence (333 residues)
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
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