About High mobility group protein B1-like 1
High mobility group protein B1-like 1 (HMGB1P1) is a protein
from Homo sapiens identified by UniProt accession
B2RPK0, 211 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | High mobility group protein B1-like 1 |
|---|
| UniProt accession | B2RPK0 |
|---|
| Gene | HMGB1P1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.21
- platelet count · score 0.19
- DNA methylation · score 0.18
- electrocardiography · score 0.18
- FEV/FVC ratio · score 0.17
- physical activity · score 0.17
- hemorrhoid · score 0.14
- mean platelet volume · score 0.14
- Red cell distribution width · score 0.14
- gut microbiome measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B2RPK0-F1 | alphafold | PREDICTED | 75.94 | — |
Amino-acid sequence (211 residues)
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HSDASVNFSE FSNKCSERWK TMSAKEKGKF EDMAKADKTH YERQMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYH PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPGEKKAAK LKEKYEKDIA AYQAKGKPEA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE DEEDEEDDDD E
Explore High mobility group protein B1-like 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets