Zinc finger and BTB domain-containing protein 42 (ZBTB42)

About Zinc finger and BTB domain-containing protein 42

Zinc finger and BTB domain-containing protein 42 (ZBTB42) is a protein from Homo sapiens identified by UniProt accession B2RXF5, 422 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Zinc finger and BTB domain-containing protein 42
UniProt accession	B2RXF5
Gene	ZBTB42
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
monocyte count · score 0.29
high density lipoprotein cholesterol measurement · score 0.26
body height · score 0.24
apolipoprotein A 1 measurement · score 0.22
appendicular lean mass · score 0.21
lethal congenital contracture syndrome · score 0.15
vitamin C measurement · score 0.09
leukocyte count · score 0.08
testosterone measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B2RXF5-F1	alphafold	PREDICTED	49.29	—

Amino-acid sequence (422 residues)

MEFPEHGGRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDRPAGS RDTVRLNGDI VTAPAFGRLL DFMYEGRLDL RSLPVEDVLA AASYLHMYDI VKVCKGRLQE KDRSLDPGNP APGAEPAQPP CPWPVWTADL CPAARKAKLP PFGVKAALPP RASGPPPCQV PEESDQALDL SLKSGPRQER VHPPCVLQTP LCSQRQPGAQ PLVKDERDSL SEQEESSSSR SPHSPPKPPP VPAAKGLVVG LQPLPLSGEG SRELELGAGR LASEDELGPG GPLCICPLCS KLFPSSHVLQ LHLSAHFRER DSTRARLSPD GVAPTCPLCG KTFSCTYTLK RHERTHSGEK PYTCVQCGKS FQYSHNLSRH TVVHTREKPH ACRWCERRFT QSGDLYRHVR KFHCGLVKSL LV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards