About BTB/POZ domain-containing protein 18
BTB/POZ domain-containing protein 18 (BTBD18) is a protein
from Homo sapiens identified by UniProt accession
B2RXH4, 712 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | BTB/POZ domain-containing protein 18 |
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| UniProt accession | B2RXH4 |
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| Gene | BTBD18 |
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| Organism | Homo sapiens |
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| Length | 712 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.08
- hypertrophic cardiomyopathy · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failures 50 · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- spermatogenic failure 25 · score 0.06
- isochromosomy Yp · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure, X-linked, 2 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B2RXH4-F1 | alphafold | PREDICTED | 49.27 | — |
Amino-acid sequence (712 residues)
MCSPASPKIL YRNPRFLRLA FLQLHHQQQS DVFCDVLLQA EGEAVPAHCC ILSACSPFFT ERLERERPAQ GGKVVLELGG LKISTLRKLV DFLYTSEMEV SQEEAQDVLS AARQLRVSEL ESLQLEGGKL VKAPQGRRLN RECLQPTSAA PISARVVTPS HHPHTPLPTN QTPCPLGAIR LKSLGKEEGP QENNRQNADN LSGTLLLKRK ARACPTPQEK NSSPSSHSQE PRENKNDTAL DPTVLSPPSL YPSVDKHLLP RKIRLSRSKP SPGICTSKPS SILSGSSSVP ATPGRRLWRQ RSVNKETPED KPKPGRASPL QSTPNPSGLG KTGGSRKRSP EVRAPNSDSA EEGQVGRVKL RKIVNGTCWE VVQETPLKNT QDSPQIPDPG GDFQEPSGTQ PFSSNEQEMS PTRTELCQDS PMCTKLQDIL VSASHSPDHP VVKSEFESSP ELVEKEPMLA IDCREPYAFD TALLEQPCEA EEYRITSAAA TSELEEILDF MLCGSDIEPP IGSLESPGAE GCRTPTYHLT ETGKNWIEGE EWCLPDMELW PRELTELEKE PAGENRGPTE LLSPLVMPSE VSEVLSVGGR WTPDLEITSS QPLDGQEDKL LHVSSLDTPQ RSYGDLSPPC SNWVETGLEV SLTTDELLYP SPKAGKEVSG HSELLGSLPA SSEEEEIDVV DWTAEGRLVP TTVPSVWPDP SSESETEVDI LT
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