Protein shisa-9 (SHISA9)

About Protein shisa-9

Protein shisa-9 (SHISA9) is a protein from Homo sapiens identified by UniProt accession B4DS77, 424 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Protein shisa-9
UniProt accession	B4DS77
Gene	SHISA9
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

unipolar depression · score 0.47
wellbeing measurement · score 0.45
neuroticism measurement · score 0.42
schizophrenia · score 0.42
bipolar disorder · score 0.41
mathematical ability · score 0.39
attention deficit hyperactivity disorder · score 0.38
depressive symptom measurement · score 0.38
intelligence · score 0.35
Tourette syndrome · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B4DS77-F1	alphafold	PREDICTED	56.71	—

Amino-acid sequence (424 residues)

MRRVLRLLLG CFLTELCARV CRAQERAGHG QLAQLGGVLL LAGGNRSGAA SGEASEGAEA SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRTPINNL HATQMNNAVP TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGSSDGDWA VSTLKSPKAD KVNDDFYTKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPPHPL AYTSTTNFKG WDPNEQSLRR QAYSNKGKLG TAETGSSDPL GTRPQHYPPP QPYFITNSKT EVTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards