About Zinc finger protein 732
Zinc finger protein 732 (ZNF732) is a protein
from Homo sapiens identified by UniProt accession
B4DXR9, 585 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Zinc finger protein 732 |
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| UniProt accession | B4DXR9 |
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| Gene | ZNF732 |
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| Organism | Homo sapiens |
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| Length | 585 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- interleukin 8 measurement · score 0.17
- cerebrospinal fluid biomarker measurement · score 0.17
- Down syndrome · score 0.05
- Shwachman-Diamond syndrome · score 0.03
- atypical hemolytic-uremic syndrome with C3 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with MCP/CD46 anomaly · score 0.03
- atypical hemolytic-uremic syndrome with I factor anomaly · score 0.03
- atypical hemolytic-uremic syndrome with thrombomodulin anomaly · score 0.03
- Blackfan-Diamond anemia · score 0.03
- tubulointerstitial kidney disease, autosomal dominant, 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B4DXR9-F1 | alphafold | PREDICTED | 69.32 | — |
Amino-acid sequence (585 residues)
MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL ISLGVAISNP DLVIYLEQRK EPYKVKIHET VAKHPAVCSH FTQDFLPVQG IEDSFHKLIL RRYEKCGHEN LELRKSCKRK VQKGGYNEFN QCLSTIQSKI FQCNVHVKVF STFSNSNQRR IRHTGEKHFK ECGKSFQKFS DLTQHQGIHA GEKPYTCEEC GKDFKWYLIF NEYEIIHTGE KPFTCEECGN IFTTSSNFAK HKVHTGEKSY KYEECGKAFN RSSTLTKHKR IHAEEKPFTC EECGKIITSS SNVAKHKKIH TGEKLYKCQE CGKVFNRSTT LTKHNRIHTG EKPYTCEECG KAFSRSSVLN EHKRIHTGEK PYKCEQCGKA FRQSATLNKH KSIHTGEKPY TCEECGKAFS RFTTLNEHKR IHTGERPHKC EECGKAFGWS TDLNKHKIIH TGEKPYKCEE CGKAFGWSAY LSKHKKIHTG EKPYRCEECG KAFLCSRALN KHKTIHTGEK PYECEECGKA FGWSTYLSKH KKIHTGEKPY RCEECGKAFR RSRVLNKYKT IHTGDKTPKC KGCGKAFKWS SYLNQHNKIY TGEKL
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