Ankyrin repeat domain-containing protein 66 (ANKRD66)

About Ankyrin repeat domain-containing protein 66

Ankyrin repeat domain-containing protein 66 (ANKRD66) is a protein from Homo sapiens identified by UniProt accession B4E2M5, 196 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 66
UniProt accession	B4E2M5
Gene	ANKRD66
Organism	Homo sapiens
Length	196 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.04
lipoprotein-associated phospholipase A(2) measurement · score 0.03
non-small cell lung carcinoma · score 0.03
central nervous system cancer · score 0.01
psoriasis · score 0.01
neoplasm · score 0.00
endometrial carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B4E2M5-F1	alphafold	PREDICTED	85.15	—

Amino-acid sequence (196 residues)

MELAKMSDMT KLHQAVAAGD YSLVKKILKK GLCDPNYKDV DWNDRTPLHW AAIKGQMEVI RLLIEYGARP CLVTSVGWTP AHFAAEAGHL NILKTLHALH AAIDAPDFFG DTPKRIAQIY GQKACVAFLE KAEPECQDHR CAAQQKGLPL DERDEDWDAK KRELELSLPS LNQNMNKKNK KSRGPTRPSN TKGRRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards