Tudor domain-containing protein 15 (TDRD15)

About Tudor domain-containing protein 15

Tudor domain-containing protein 15 (TDRD15) is a protein from Homo sapiens identified by UniProt accession B5MCY1, 1934 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Tudor domain-containing protein 15
UniProt accession	B5MCY1
Gene	TDRD15
Organism	Homo sapiens
Length	1934 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.51
total cholesterol measurement · score 0.45
alcohol drinking · score 0.38
hematocrit · score 0.37
free cholesterol measurement · score 0.35
coronary artery disease · score 0.35
alcohol consumption measurement · score 0.34
vitamin D measurement · score 0.34
self reported educational attainment · score 0.33
triglyceride measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B5MCY1-F1	alphafold	PREDICTED	71.66	—

Amino-acid sequence (1934 residues)

MDSTSFLPTF LDVDLTISHI KCLPKDILVK FQGIKSNECE FDYHVLQREI QHTPKVKNNV EIDEFCLVEE RVSGEWQRGR VMEKKNELYT VLLIDRGEEL RVAGPQIASA CGNLFELPPR VVFGIFANIL PVGEKWSPKA LNYFKSLVGI QVKGYVQAIL PLQMFLFEVP KIISQALELQ LGRLVDGDSF RLIVEMLEEF PQQMPDLLQH KRPELSLGNK DTSLDIQHVL DKLQPSLSVG STESVKVSSA LSPSKFYCQL IKWTPELENL TAHMTLHYDT VCQETSPTCD NFGLLCVARR RNGQWHRGIL QQLLPPNQVK IWFMDYGSSE AIPSIYVKKL KQDFILVPLF SFPCSLTCLH SPDRDARIFQ LSIFKQALLG QVVYAHIDWF NKDECLYYVT LQTQESTVNS KCLLKTVGTQ VLCPMSDSKI SNILSETSVS DVNSFAVESF MGNIEWSIDS LNKKGILKVG FPIKTVQMEI EAAYIAFIAY VLNPSNFWVR TNDHRNEFQE IMKNINKFYD LCENDEMILR KPEPGLFCCA RYSKDRRFYR AVITEINGYK INVYFLDYGN TDSIPFFDVK ILLPEFCELP ALAMCCSLAH IFPVEDLWTK AAIDYFKKLV LNKAILLQVI AKKDDKYTVN IQSVEASENI DVISLMLQAG YAEYFQVELE YFPKSVSEYS MLNSESKNKV NIKKVISALL EGPKSKKYHS NNLVENNLSL PKSLAVNISE FKNPFTLSVG PESSWPYKEY IFRPGTVLEV KCSCYYGPGD FSCQLQCKSE DLKLLMEQIQ NYYSIHSDPY EIGQTACVAK YSGKWCRAAV LTQVSKEVDI VFVDYGYQKR VLIEDLCAIN PRFLLLESQA FRCCLNHFIE PVSCKLFSWT RKAFRDLWNF ISSSRGLLTC IIYALVIIHP NHLYNLVDLQ SSFTSAKEFL MNRGSAQYIT LSETFPSLFS LYSYCYSSFN IQIGSEEEVY ISHIYSPQKF YCQLGRNNKD LEMIETKITE SVNLQNFPKY DSNKMRVCIS KYVEDGLSYR ALAIPTDSSS EFQVYFVDFG NKQLVGENML RAISAQFPEL LFTPMQAIKC FLSDLRDVDI PAEISSWFKD NFLGRSLKAI ILSQESDGQL GIELYDGSQY INEKIKVLLH AYGKRHCDQA CCMEKSNKIN ENKRFTTSLK GKTGNNYRHN VINKPSPVTY SERKIDQLMH PKNIHARFLK PSVCYKMEPV SKNKMKTSLN DGLKGIKIVP GAAHILENRR VGQKSVKVVS QSFIRALNQT TSQNPYDLIR PQIKDLPQPQ IYLNAKVKGY VSNISNPANF HIQLAENESV IIRLADALNA TARRLRERKS VKPLVGDLVV AEYSGDNAIY RAVIKKILPG NSFEVEFIDY GNSAIVNTSK IYELQREFLT VPQLGIHAFL SGVKWNEPDE IWDDKTVDYF TSKVHNKTVY CEFLKKHDQK WEVNMICDEK CVINELLKWK ACSKLQKSAL QMPQVLSQKV RPGDNEMKKG KSNESEGSMN SNQQLFKIPL EEFKLGQLEK AEMLNVSKSG RFYVKLSKNK KILSDLIVLI TKEEKKSPFL SMESIEKGLE CLAKSKNTLK WHRSKVEEKY VDDKVLVFLV DCGIYEIVPV CNTKLLSNEI RNIPRQAVPC KWIWFENSKN ISFECLFADL EINILFLKYL DAVWEVEILV DDLLLLEYLN LNTVPVEENK LRLAEIVYNI ESKTPVSSCT IKSFTWVQFQ NDRQYSGIAT AVSDPSDFSI QLEDFFDIMK YLFMLLSDLP ETLQTLPQEF IIPGSSCLFK YKSEDQWNRV EISEVSPQSL CLVLVDYGFS FYIRYSEIIN LKVVPEELLN LPRLSYPCIL YGILPAKGKH WSEEAKIFFR DFLSKPDLVF QFREYHSETK LKVDVIHEKN NLADILVASG LATYSKDSPH LDAITATESA KNPI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards