Glutathione hydrolase light chain 3 (GGTLC3)

About Glutathione hydrolase light chain 3

Glutathione hydrolase light chain 3 (GGTLC3) is a protein from Homo sapiens identified by UniProt accession B5MD39, 225 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.

Target properties

Protein name	Glutathione hydrolase light chain 3
UniProt accession	B5MD39
Gene	GGTLC3
Organism	Homo sapiens
Length	225 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (171)

Diseases linked to this target (Open Targets).

46,XX gonadal dysgenesis · score 0.05
multiple epiphyseal dysplasia, with severe proximal femoral dysplasia · score 0.05
hypogonadotropic hypogonadism · score 0.05
Kallmann syndrome · score 0.05
multiple epiphyseal dysplasia · score 0.05
multiple epiphyseal dysplasia type 4 · score 0.05
Isolated follicle stimulating hormone deficiency · score 0.05
hypergonadotropic hypogonadism-cataract syndrome · score 0.05
spondyloepimetaphyseal dysplasia, Missouri type · score 0.05
Gollop-Wolfgang complex · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B5MD39-F1	alphafold	PREDICTED	92.84	—

Amino-acid sequence (225 residues)

MTSEFFAAQL RSQISDHTTH PISYYKPEFY TPDDGGTAHL SVVAEDGSAV SATSTINLYF GSKVCSPVSG ILFNNEWTTS ALPAFTNEFG APPSPANFIQ PGKQPLLSMC PTIMVGQDGQ VRMVVGAAGG TQITTDTALA IIYNLWFGYD VKRAVEEPRL HNKLLPNVTT VERNIDQAVT AALETRHHHT QIASTFIAVV QAIVRTAGGW AAASDSRKGG EPAGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards