About Eukaryotic translation initiation factor 3 subunit C-like protein
Eukaryotic translation initiation factor 3 subunit C-like protein (EIF3CL) is a protein
from Homo sapiens identified by UniProt accession
B5ME19, 914 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit C-like protein |
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| UniProt accession | B5ME19 |
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| Gene | EIF3CL |
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| Organism | Homo sapiens |
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| Length | 914 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.11
- mathematical ability · score 0.11
- celiac disease · score 0.11
- autoimmune disease · score 0.11
- psoriasis · score 0.11
- autoimmune thyroid disease · score 0.11
- juvenile idiopathic arthritis · score 0.11
- ankylosing spondylitis · score 0.11
- ulcerative colitis · score 0.11
- type 1 diabetes mellitus · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B5ME19-F1 | alphafold | PREDICTED | 73.62 | — |
Amino-acid sequence (914 residues)
MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEL WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG SSDEDEDEDG VSAATFLKKK SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS DSEEEEGKQT ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEEDNEGG EWERVRGGVP LVKEKPKMFA KGTEITHAVV IKKLNEILQA RGKKGTDRAA QIELLQLLVQ IAAENNLGEG VIVKIKFNII ASLYDYNPNL ATYMKPEMWG KCLDCINELM DILFANPNIF VGENILEESE NLHNADQPLR VRGCILTLVE RMDEEFTKIM QNTDPHSQEY VEHLKDEAQV CAIIERVQRY LEEKGTTEEV CRIYLLRILH TYYKFDYKAH QRQLTPPEGS SKSEQDQAEN EGEDSAVLME RLCKYIYAKD RTDRIRTCAI LCHIYHHALH SRWYQARDLM LMSHLQDNIQ HADPPVQILY NRTMVQLGIC AFRQGLTKDA HNALLDIQSS GRAKELLGQG LLLRSLQERN QEQEKVERRR QVPFHLHINL ELLECVYLVS AMLLEIPYMA AHESDARRRM ISKQFHHQLR VGERQPLLGP PESMREHVVA ASKAMKMGDW KTCHSFIINE KMNGKVWDLF PEADKVRTML VRKIQEESLR TYLFTYSSVY DSISMETLSD MFELDLPTVH SIISKMIINE ELMASLDQPT QTVVMHRTEP TAQQNLALQL AEKLGSLVEN NERVFDHKQG TYGGYFRDQK DGYRKNEGYM RRGGYRQQQS QTAY
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