About Inward rectifier potassium channel 18
Inward rectifier potassium channel 18 (KCNJ18) is a protein
from Homo sapiens identified by UniProt accession
B7U540, 433 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Inward rectifier potassium channel 18 |
|---|
| UniProt accession | B7U540 |
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| Gene | KCNJ18 |
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| Organism | Homo sapiens |
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| Length | 433 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- thyrotoxic periodic paralysis · score 0.27
- protein measurement · score 0.13
- Blackfan-Diamond anemia · score 0.05
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- hemoglobin D disease · score 0.04
- Heinz body anemia · score 0.04
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-B7U540-F1 | alphafold | PREDICTED | 80.64 | — |
Amino-acid sequence (433 residues)
MTAASRANPY SIVSLEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIAFANM DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGV IFWVIAVAHG DLEPAEGHGR TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECLVAVF MVVAQSIVGC IIDSFMIGAI MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG VLEQRPYRRG SEI
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