Protein phosphatase 1 regulatory subunit 3G (PPP1R3G)

About Protein phosphatase 1 regulatory subunit 3G

Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) is a protein from Homo sapiens identified by UniProt accession B7ZBB8, 358 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 3G
UniProt accession	B7ZBB8
Gene	PPP1R3G
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

neuroinflammatory disorder · score 0.32
diet measurement · score 0.28
Red cell distribution width · score 0.25
lung adenocarcinoma · score 0.08
metabolite measurement · score 0.06
obesity due to melanocortin 4 receptor deficiency · score 0.03
neoplasm · score 0.03
basal cell carcinoma · score 0.02
squamous cell carcinoma · score 0.02
keratinocyte carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B7ZBB8-F1	alphafold	PREDICTED	67.80	—

Amino-acid sequence (358 residues)

MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP DAQLGDRPLS PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ QQQQQAVALG GEGAEDAQLG PGGCCAKCKK RVQFADTLGL SLASVKHFSE AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL LAAAAVAAPL SAPPSRLRPL FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL SCPGPRAVTV RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR YARPADAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards