Protein shisa-8 (SHISA8)

About Protein shisa-8

Protein shisa-8 (SHISA8) is a protein from Homo sapiens identified by UniProt accession B8ZZ34, 397 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Protein shisa-8
UniProt accession	B8ZZ34
Gene	SHISA8
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.22
creatinine measurement · score 0.13
glomerular filtration rate · score 0.13
diet measurement · score 0.07
eosinophil count · score 0.05
lymphocyte count · score 0.05
body weight · score 0.04
non-small cell lung carcinoma · score 0.02
birth weight · score 0.02
refractive error · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-B8ZZ34-F1	alphafold	PREDICTED	56.93	—

Amino-acid sequence (397 residues)

MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS ADKKRLNNAP RGSAAPGPPR GPRLQGGGSL TLQPDYAKYA TFKAAALKAA EAAPRDFCQR FPALEPSPRQ PPARAPRPSP DLPAPLDACP WAPPVYAPPA APGPYAAWTS SRPARPAPLS HPTARAFQVP RRPGHAARRQ FSVKMPETFN PQLPGLYGSA GRGSRYLRTN SKTEVTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards