KRAB domain-containing protein 1 (KRABD1)

About KRAB domain-containing protein 1

KRAB domain-containing protein 1 (KRABD1) is a protein from Homo sapiens identified by UniProt accession C9JBD0, 128 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	KRAB domain-containing protein 1
UniProt accession	C9JBD0
Gene	KRABD1
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

monocyte count · score 0.27
neurodegenerative disease · score 0.26
neutrophil count · score 0.24
eosinophil count · score 0.24
myeloid white cell count · score 0.22
lymphocyte percentage of leukocytes · score 0.22
leukocyte count · score 0.21
granulocyte count · score 0.17
sum of basophil and neutrophil counts · score 0.17
monocyte percentage of leukocytes · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-C9JBD0-F1	alphafold	PREDICTED	66.93	—

Amino-acid sequence (128 residues)

MMTAVSLTTR PQESVAFEDV AVYFTTKEWA IMVPAERALY RDVMLENYEA VAFVVPPTSK PALVSHLEQG KESCFTQPQG VLSRNDWRAG WIGYLELRRY TYLAKAVLRR IVSKIFRNRQ CWEDRRKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards