About Claudin-25
Claudin-25 (CLDN25) is a protein
from Homo sapiens identified by UniProt accession
C9JDP6, 229 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Claudin-25 |
|---|
| UniProt accession | C9JDP6 |
|---|
| Gene | CLDN25 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 229 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- alcohol consumption measurement · score 0.18
- sex hormone-binding globulin measurement · score 0.09
- smoking status measurement · score 0.08
- PR interval · score 0.07
- parental longevity · score 0.06
- longevity · score 0.05
- healthspan · score 0.05
- self reported educational attainment · score 0.05
- serum non-albumin protein measurement · score 0.04
- unipolar depression · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-C9JDP6-F1 | alphafold | PREDICTED | 83.05 | — |
Amino-acid sequence (229 residues)
MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI WEVCVDREEV ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF GSECFQFHRI RWVFKRRLGL LGRTLEASAS ATTLLPVSWV AHATIQDFWD DSIPDIIPRW EFGGALYLGW AAGIFLALGG LLLIFSACLG KEDVPFPLMA GPTVPLSCAP VEESDGSFHL MLRPRNLVI
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