About Protein PAT1 homolog 2
Protein PAT1 homolog 2 (PATL2) is a protein
from Homo sapiens identified by UniProt accession
C9JE40, 543 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Protein PAT1 homolog 2 |
|---|
| UniProt accession | C9JE40 |
|---|
| Gene | PATL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 543 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- Female infertility due to fertilization defect · score 0.72
- female infertility due to oocyte meiotic arrest · score 0.37
- genetic disorder · score 0.19
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- transient myeloproliferative syndrome · score 0.05
- Testicular regression syndrome · score 0.04
- Young syndrome · score 0.04
- familial hyperprolactinemia · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-C9JE40-F1 | alphafold | PREDICTED | 64.60 | — |
Amino-acid sequence (543 residues)
MNCLEGPGKT CGPLASEEEL VSACQLEKEE ENEGEEEEEE EDEEDLDPDL DPDLEEEEND LGDPAVLGAV HNTQRALLSS PGVKAPGMLG MSLASLHFLW QTLDYLSPIP FWPTFPSTSS PAQHFGPRLP SPDPTLFCSL LTSWPPRFSH LTQLHPRHQR ILQQQQHSQT PSPPAKKPWS QQPDPYANLM TRKEKDWVIK VQMVQLQSAK PRLDDYYYQE YYQKLEKKQA DEELLGRRNR VESLKLVTPY IPKAEAYESV VRIEGSLGQV AVSTCFSPRR AIDAVPHGTQ EQDIEAASSQ RLRVLYRIEK MFLQLLEIEE GWKYRPPPPC FSEQQSNQVE KLFQTLKTQE QNNLEEAADG FLQVLSVRKG KALVARLLPF LPQDQAVTIL LAITHHLPLL VRRDVADQAL QMLFKPLGKC ISHLTLHELL QGLQGLTLLP PGSSERPVTV VLQNQFGISL LYALLSHGEQ LVSLHSSLEE PNSDHTAWTD MVVLIAWEIA QMPTASLAEP LAFPSNLLPL FCHHVDKQLV QQLEARMEFA WIY
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