Proline, histidine and glycine-rich protein 1 (PHGR1)

About Proline, histidine and glycine-rich protein 1

Proline, histidine and glycine-rich protein 1 (PHGR1) is a protein from Homo sapiens identified by UniProt accession C9JFL3, 82 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Proline, histidine and glycine-rich protein 1
UniProt accession	C9JFL3
Gene	PHGR1
Organism	Homo sapiens
Length	82 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.20
BMI-adjusted waist circumference · score 0.16
diverticular disease · score 0.12
intelligence · score 0.09
Barrett's esophagus · score 0.09
cognitive function measurement · score 0.09
self reported educational attainment · score 0.09
verbal-numerical reasoning measurement · score 0.07
diverticulitis · score 0.07
asthma · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-C9JFL3-F1	alphafold	PREDICTED	46.94	—

Amino-acid sequence (82 residues)

MDPGPKGHCH CGGHGHPPGH CGPPPGHGPG PCGPPPHHGP GPCGPPPGHG PGPCGPPPHH GPGPCGPPPG HGPGHPPPGP HH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards