About HERV-H LTR-associating protein 1
HERV-H LTR-associating protein 1 (HHLA1) is a protein
from Homo sapiens identified by UniProt accession
C9JL84, 531 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | HERV-H LTR-associating protein 1 |
|---|
| UniProt accession | C9JL84 |
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| Gene | HHLA1 |
|---|
| Organism | Homo sapiens |
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| Length | 531 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.28
- neurodegenerative disease · score 0.21
- PHF-tau measurement · score 0.09
- breast carcinoma · score 0.04
- Ataxia-telangiectasia · score 0.01
- neoplasm · score 0.01
- cancer · score 0.01
- Klinefelter's syndrome · score 0.00
- metastatic neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-C9JL84-F1 | alphafold | PREDICTED | 43.03 | — |
Amino-acid sequence (531 residues)
MLGFLSRGPS MKLCMGLACV LSLWNTVSGI KGEAKKEKGM TFLPTTVSGL REEERKEKGV AFLATTELPA RSIDLSALNL TELVNGMLSR ALKDSKKFFS LLSVTSYSSF AFHKFSVAVY NISNLKTVDP AKFPTRYCYC LNNRTNDLSD FTALLVDIIG NSTSYLTEIF KSTSILSVNQ SNESDCIFIC VMTGKSGRNL SDFWEIEEKY PIINYTFTSG LSGVLGAATR GTARTSKPTT KSQKTLPSTS PGHWTQSTPW ASALRSSPWT ETAAPSETEE TLNTGRPPEL PARATATWFS ASHTLPALAT RRVARTQWLT ADRQTWASIS SVPWAQTISE KKPGGSLWET RSSPPTTAGT EEAMNTTSLL APAAEIMATP GSPSQASPTL GAFTHGTQTP SPTKATAPRY PQTGDLSAEW PFTAGEEPVL VPRPHQVSRC PQPLFKVGAM AAAPLTLAIQ RLNPCLMELC QFFQQCLCMS QRSPRTEDMR YCLEYYSWFL KNATYICQRV KRVSHSHTLK QKCLENICKS V
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