Zinc finger protein 878 (ZNF878)

About Zinc finger protein 878

Zinc finger protein 878 (ZNF878) is a protein from Homo sapiens identified by UniProt accession C9JN71, 531 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Zinc finger protein 878
UniProt accession	C9JN71
Gene	ZNF878
Organism	Homo sapiens
Length	531 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
body height · score 0.14
X-linked retinal dysplasia · score 0.07
age-related macular degeneration · score 0.06
Familial exudative vitreoretinopathy · score 0.06
Down syndrome · score 0.06
choroidal dystrophy, central areolar, 1 · score 0.05
severe early-childhood-onset retinal dystrophy · score 0.05
Familial drusen · score 0.04
age related macular degeneration 7 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-C9JN71-F1	alphafold	PREDICTED	78.72	—

Amino-acid sequence (531 residues)

MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ YIEDEHQNPR RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ SYESSVCGEI GIGLSSLNRH LRAFSYSSSL AIHGRTHTGE KPYECKECGK AFRFPSSVRR HERIHSAKKP YECKQCGKAF SFPSSVRRHE RIHSAKKPYE CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS SLKRHEKSHT GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF VKDLRIHERT HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC GKAFRSASVL QKHIRTHTGE KPYGCKQCGK VFRVASQLKM HERTHTGEKP YECKQCGKAF ISSNSIRYHK RTHTGEKPYK CKQCGKAFIS SNSFLYHERI HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards