About Kelch repeat and BTB domain-containing protein 13
Kelch repeat and BTB domain-containing protein 13 (KBTBD13) is a protein
from Homo sapiens identified by UniProt accession
C9JR72, 458 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 13 |
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| UniProt accession | C9JR72 |
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| Gene | KBTBD13 |
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| Organism | Homo sapiens |
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| Length | 458 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (91)
Diseases linked to this target (Open Targets).
- nemaline myopathy 6 · score 0.75
- neurodegenerative disease · score 0.43
- childhood-onset nemaline myopathy · score 0.37
- genetic disorder · score 0.19
- nemaline myopathy 3 · score 0.12
- severe congenital nemaline myopathy · score 0.12
- white matter hyperintensity measurement · score 0.06
- paramyotonia congenita of Von Eulenburg · score 0.05
- Distal myopathy, Nonaka type · score 0.05
- congenital diaphragmatic hernia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-C9JR72-F1 | alphafold | PREDICTED | 90.24 | — |
Amino-acid sequence (458 residues)
MARGPQTLVQ VWVGGQLFQA DRALLVEHCG FFRGLFRSGM RETRAAEVRL GVLSAGGFRA TLQVLRGDRP ALAAEDELLQ AVECAAFLQA PALARFLEHN LTSDNCALLC DAAAAFGLRD VFHSAALFIC DGERELAAEL ALPEARAYVA ALRPSSYAAV STHTPAPGFL EDASRTLCYL DEEEDAWRTL AALPLEASTL LAGVATLGNK LYIVGGVRGA SKEVVELGFC YDPDGGTWHE FPSPHQPRYD TALAGFDGRL YAIGGEFQRT PISSVERYDP AAGCWSFVAD LPQPAAGVPC AQACGRLFVC LWRPADTTAV VEYAVRTDAW LPVAELRRPQ SYGHCMVAHR DSLYVVRNGP SDDFLHCAID CLNLATGQWT ALPGQFVNSK GALFTAVVRG DTVYTVNRMF TLLYAIEGGT WRLLREKAGF PRPGSLQTFL LRLPPGAPGP VTSTTAEL
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