Aldo-keto reductase family 1 member B15 (AKR1B15)

About Aldo-keto reductase family 1 member B15

Aldo-keto reductase family 1 member B15 (AKR1B15) is a protein from Homo sapiens identified by UniProt accession C9JRZ8, 316 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member B15
UniProt accession	C9JRZ8
Gene	AKR1B15
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
ovarian cancer · score 0.18
squamous cell lung carcinoma · score 0.16
hypertension · score 0.14
Agents acting on the renin-angiotensin system use measurement · score 0.13
Calcium channel blocker use measurement · score 0.12
head and neck squamous cell carcinoma · score 0.11
systolic blood pressure · score 0.08
diastolic blood pressure · score 0.08
cardiovascular disease · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-C9JRZ8-F1	alphafold	PREDICTED	97.70	—

Amino-acid sequence (316 residues)

MATFVELSTK AKMPIVGLGT WRSLLGKVKE AVKVAIDAEY RHIDCAYFYE NQHEVGEAIQ EKIQEKAVMR EDLFIVSKVW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKTGD DFFPKDDKGN MISGKGTFLD AWEAMEELVD EGLVKALGVS NFNHFQIERL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTTAQVLI RFHIQRNVTV IPKSMTPAHI VENIQVFDFK LSDEEMATIL SFNRNWRAFD FKEFSHLEDF PFDAEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards