About Ubiquitin carboxyl-terminal hydrolase 17-like protein 21
Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 (USP17L21) is a protein
from Homo sapiens identified by UniProt accession
D6R901, 530 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 |
|---|
| UniProt accession | D6R901 |
|---|
| Gene | USP17L21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 530 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- immunodeficiency 19 · score 0.04
- urate measurement · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.03
- severe combined immunodeficiency due to IKK2 deficiency · score 0.03
- ring chromosome Y · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- severe combined immunodeficiency due to LAT deficiency · score 0.03
- obesity due to congenital leptin deficiency · score 0.03
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-D6R901-F1 | alphafold | PREDICTED | 67.80 | — |
Amino-acid sequence (530 residues)
MEEDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR QLAPREKLPL SNRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN AYHCGVCLQR APASKMLTLL TSAKVLILVL KRFSDVTGNK IAKNVQYPEC LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Explore Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets