About Cilia- and flagella-associated protein 99
Cilia- and flagella-associated protein 99 (CFAP99) is a protein
from Homo sapiens identified by UniProt accession
D6REC4, 646 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 99 |
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| UniProt accession | D6REC4 |
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| Gene | CFAP99 |
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| Organism | Homo sapiens |
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| Length | 646 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (7)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.06
- YKL40 measurement · score 0.04
- inflammatory biomarker measurement · score 0.04
- health study participation · score 0.02
- squamous cell carcinoma · score 0.01
- acute myeloid leukemia · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-D6REC4-F1 | alphafold | PREDICTED | 76.67 | — |
Amino-acid sequence (646 residues)
MAYYGKCIET VIEQLDKFTP KRDNPEQFLE AAATSLQALS PQKQSFVLEV LSGCLEYRKL LTVVVDAFYV EDGRLCLRVD HSRFEVICYL ATFLLEELGF QLFCNIIKSQ PVDKMCKFLR FFFNPLHLCS WIKDEWSLIY EPAHVKENWI DPLMRWQPEV QELINHLEGV SASQSSPLKT KAKVTEPKEF NLTAPRPRTI PAPEPVPVVA KPRPVPQSTY QPPKEQQQLE TVKRYNRRKA EELLLRANIE ELRCAMPRSC RERVQGSKQQ LRLQFPPRIR KTPKLTFYRP DNILVKLNTT AILREGALYQ RQVEQELQRV DKLVDGAGDF SEFFEWQKKM QAKDREEQLA ASECRRLQGK LSHEEAVLAR QSLMQENKQR VEQQKEQMAK LMLQRAERRL REDRSRKELV EQVIEGQKNA KAAQTKLAKG RQQTVQEAIE ESRGLLQRRA QAAQEEQRRR CELISQLRAL ETQPTRKGKL VDLTQIPGYG LEGEMSIVEL RERLALLKEN QRRKEEEKRD QIIQGKHTKS QELQNMVEQI SLCRAAMGRS AALRWEEKKA LAAAPAAPSQ DERVQQLRRR ISERAAERSR QAALLHVSAP RTARPKPRAQ LEAQHWLELE RSRERRLQAL QQGGSGPGPA RRLEAA
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