About Uncharacterized protein C4orf54
Uncharacterized protein C4orf54 (C4orf54) is a protein
from Homo sapiens identified by UniProt accession
D6RIA3, 1793 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Uncharacterized protein C4orf54 |
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| UniProt accession | D6RIA3 |
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| Gene | C4orf54 |
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| Organism | Homo sapiens |
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| Length | 1793 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- body height · score 0.42
- sitting height measurement · score 0.33
- BMI-adjusted hip circumference · score 0.28
- platelet component distribution width · score 0.28
- appendicular lean mass · score 0.09
- vital capacity · score 0.04
- Tetralogy of Fallot · score 0.04
- pancreatic adenocarcinoma · score 0.03
- alcohol use disorder measurement · score 0.03
- mean corpuscular volume · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-D6RIA3-F1 | alphafold | PREDICTED | 39.89 | — |
Amino-acid sequence (1793 residues)
MLSFHFWKSR GQPTDAASSV ADGIQTPRCC RRCQANNWTG QLSYRTLATV SAGAAAPQPQ TTSTASSRSL PTSLRLAAAP PQGLKNWEVV AAVAAVPTAL GPVQIRGTLL RATLQPLRGQ RRTQDFPSDH HCLFLSLKPG QGLIMEAAPP ELNSKARQAE VGDGVSSAQD SQELKQQLWP LPKPSASSQR EAKYVDMCAS AEVQRESPQT MKLTLGHCPG GQRASRSPKE KAQDEPSSKT PSPQNNPASS QLSRSQHSAS EEGGNFSSSS SSSPMNKAEE DGLSKMEDST TSTGALATSS SSLGFESESG ESEGCQAVGG EGEKISGGGG GGKGGGGGGA GDGTECRDII AKSQGSRDPP KVEEAHYITT HEIQLSEVEQ DMDFDVGLAS RWDFEDNNVI YSFVDYASFG GSDETPGDIT SLTEEDDDNS CYLSTTPSTN TTRTPSPTSS DLARPNAGRS GRDTSSTEVG SGPSDSGPTP PPTGPGTAPL TEPLPETPEA ASGAAAAAAS SCGSAASQIL LSIKPASRAI NEPSNVRAKQ NIIYAAKHEG DMSLRVSTAA EHNSSSLKQN PAAAVAQDHA KKFIAVPARL QTRCGAIRAK ELVDYSSGAS SAVSELDDAD KEVRNLTSRA FRSLAYPYFE ALNISSRESS TTLSEVGFGR WSTFLDLKCG GVGARVEQSL LRSSAASVAA GLRKGSGARA TADQLYIQSK KSQTKALEFV VSKVEGEIKH VETPLCFQKQ VQTGSRVVTL LEPLNVRSES KASSAPGPGR ATKGPGKGPG SAYTDDGSET SEGSKPTSRA DGPQKSKFAS SLLKNVISKK MQREHEFKME RGEVMDTSHH LSGTSKETEG ARGSERQRER GLQRQSSRHS EAGSEYTVVS MSDAGGEGSV AGSKSPVFKA STPRERNAGP GRNFTDGHTE VCEIKKSASE TVKGIFLRSQ NSAFRSWKEK EAEKREEQAP IGKLKLPKGG DWRADLGEIS ASKNTIMSRL FVPNIQQTPK DKQPRKQATK YPAAQATSTA VIRPKAPEIK IRLGSVQQPS SDFNIAKLLT PKLAGGSASN LFKTIEDNSR AQQKLFRGDN LEKVPHFQVR DIRDKSKAQG PLHQVRDVRK LIKGSGDSSD KGSVTPEQGL TGPKPRQLSA AAGGSGSLSP MVITCQAVVN QREDSMDREP RESMGKGGGS RVLNSSSPEG TVLVHRASGR LPVATIAPNK PEQGSYLPVL KIVSKASTQK TPEKLKEEEV KEEGKATKPA RNALEKLTAA VRSMEELYSF NRNEWKRKSD PLPMMMDSHV LSLIASEERE GVVVADGDHD KLSKRLGEVE ERGTGNKAGV VLRGAPIERL QRRNSNPSAE SVSARAAAFE NLARERPRSL YIPPVHKDVE RTQPLQPLPP LPSNRNVFTV SASSIQKTGG VAGKFPQGPS PESPSAAKGI KSQGLRSLKI SPATRAPPDE VTNRKSGSNL EKSNSDCENY LTIPLKGSSA AGELLSRPGA SREGPPNSSA ATLCSLPPLS ARSQVPSSSK GSQVSGTSRP AWRTKPDNPR ETVAAPPGPQ SPEHPPTTIY HQPPLPFTLQ GAQPQVLCFS PPSMPAPAPA ASAPVPTDPF QQAQPQQTQR KMLLDVTTGQ YYLVDTPVQP MTRRLFDPET GQYVDVPMTS QQQAVAPMSI SVPPLALSPG AYGPTYMIYP GFLPTVLPTN ALQPTPIARA PRGSELSPMV AEPSSKEAAA TFTEAPYFMA SGQSPASSTS SAPAATSQLL GAKAFAQLHG KPVISITSQP LGPRIIAPPS FDGTTMSFVV EHR
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