Ankyrin repeat domain-containing protein 65 (ANKRD65)

About Ankyrin repeat domain-containing protein 65

Ankyrin repeat domain-containing protein 65 (ANKRD65) is a protein from Homo sapiens identified by UniProt accession E5RJM6, 399 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 65
UniProt accession	E5RJM6
Gene	ANKRD65
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
diastolic blood pressure · score 0.17
refractive error measurement · score 0.11
systolic blood pressure · score 0.05
Drugs affecting bone structure and mineralization use measurement · score 0.04
von Willebrand factor measurement · score 0.03
eosinophil count · score 0.03
colorectal cancer · score 0.01
prostate carcinoma · score 0.01
calf circumference measurement · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-E5RJM6-F1	alphafold	PREDICTED	85.40	—

Amino-acid sequence (399 residues)

MDSQRPEPRE EEEEEQELRW MELDSEEALG TRTEGPSVVQ GWGHLLQAVW RGPAGLVTQL LRQGASVEER DHAGRTPLHL AVLRGHAPLV RLLLQRGAPV GAVDRAGRTA LHEAAWHGHS RVAELLLQRG ASAAARSGTG LTPLHWAAAL GHTLLAARLL EAPGPGPAAA EAEDARGWTA AHWAAAGGRL AVLELLAAGG AGLDGALLVA AAAGRGAALR FLLARGARVD ARDGAGATAL GLAAALGRSQ DIEVLLGHGA DPGIRDRHGR SALHRAAARG HLLAVQLLVT QGAEVDARDT LGLTPLHHAS REGHVEVAGC LLDRGAQVDA TGWLRKTPLH LAAERGHGPT VGLLLSRGAS PTLRTQWAEV AQMPEGDLPQ ALPELGGGEK ECEGIESTG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards