About Proline-rich basic protein 1
Proline-rich basic protein 1 (PROB1) is a protein
from Homo sapiens identified by UniProt accession
E7EW31, 1015 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Proline-rich basic protein 1 |
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| UniProt accession | E7EW31 |
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| Gene | PROB1 |
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| Organism | Homo sapiens |
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| Length | 1015 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.31
- keratoconus 1 · score 0.11
- systolic blood pressure · score 0.10
- hypertrophic cardiomyopathy · score 0.09
- appendicular lean mass · score 0.05
- creatinine measurement · score 0.02
- urate measurement · score 0.02
- COVID-19 · score 0.02
- keratoconus · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-E7EW31-F1 | alphafold | PREDICTED | 44.34 | — |
Amino-acid sequence (1015 residues)
MLTALAPPAL PGIPRQLPTA PARRQDSSGS SGSYYTAPGS PEPPDVGPDA KGPANWPWVA PGRGAGAQPR LSVSAQNSRQ RHGPGSGFPR GPGSGPRPPQ PQLRTLPSGE MEVIFGVGPL FGCSGADDRE AQQQFTEPAF ISPLPPGPAS PAAVPRQSQV PDGGSRWATY LELRPRGPSP AAPAQFECVE VALEEGAAPA RPRTVPKRQI ELRPRPQSPP RAAGAPRPRL LLRTGSLDES LGPLQAAAGF VQTALARKLS PEAPAPSSAT FGSTGRSEPE TRETARSTHV VLEKAKSRPL RVRDNSAPAK APRPWPSLRE RAIRRDKPAP GTEPLGPVSS SIFLQSEEKI QEARKTRFPR EAPDRTVQRA RSPPFECRIP SEVPSRAVRP RSPSPPRQTP NGAVRGPRCP SPQNLSPWDR TTRRVSSPLF PEASSEWENQ NPAVEETVSR RSPSPPILSQ WNQCVAGERS PSLEAPSLWE IPHSAVADAV EPRSSPSPPA FFPWEAPDRP IGTWGPSPQE TWDPMGPGSS IAFTQEAQNG LTQEELAPPT PSAPGTPEPT EMQSPSTREI SDLAFGGSQQ SPEVAAPEPP GSHPVGTLDA DKCPEVLGPG EAASGRPRMA IPRPRDVRKL VKTTYAPGFP AGAQGSGLPA PPADPCGEEG GESKTQEPPA LGPPAPAHYT SVFIKDFLPV VPHPYEPPEP SFDTVARDAS QPNGVLRRRA ENSTAKPFKR TEIRLPGALA LGRRPEVTSR VRARGPGGEN RDVEAQRLVP DGDGRTSPLG GARSSSQRSP VGPAGVRSPR PGSPQMQASP SPGIAPKPKT PPTAPEPAAA VQAPLPREPL ALAGRTAPAQ PRAASAPPTD RSPQSPSQGA RRQPGAAPLG KVLVDPESGR YYFVEAPRQP RLRVLFDPES GQYVEVLLPP SSPGPPHRVY TPLALGLGLY PPAYGPIPSL SLPPSPGPQA LGSPQLPWVS EAGPLDGTYY LPVSGTPNPA PPLLLCAPPS SSGPTQPGKG SLFPL
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