About Nuclear pore complex-interacting protein family member B6
Nuclear pore complex-interacting protein family member B6 (NPIPB6) is a protein
from Homo sapiens identified by UniProt accession
E9PJ23, 425 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Nuclear pore complex-interacting protein family member B6 |
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| UniProt accession | E9PJ23 |
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| Gene | NPIPB6 |
|---|
| Organism | Homo sapiens |
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| Length | 425 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (49)
Diseases linked to this target (Open Targets).
- body mass index · score 0.26
- grip strength measurement · score 0.18
- intelligence · score 0.14
- type 1 diabetes mellitus · score 0.12
- mathematical ability · score 0.11
- psoriasis · score 0.11
- Crohn's disease · score 0.11
- self reported educational attainment · score 0.11
- cognitive function measurement · score 0.11
- HbA1c measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-E9PJ23-F1 | alphafold | PREDICTED | 52.28 | — |
Amino-acid sequence (425 residues)
MVKLSIVLTP QFLSHDQSQL TKELQQHVKS VTCPCEYLRK VINSLAVYRH RETDFGVGVR DHPGQHGKTP SPQKLDNLII IIIGFLRRYT FNILFCTSCL CVSFLKTIFW SRNGHDGSMD VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF RGNKIGLKDV ITLRRHVETK VRAKIRKRKV TTKINRHDKI NGKRKTARKQ KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMVAAEH RHSSGLPYWP YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPTECLLT PLPPSVDDNI KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKTPPLATQ EAEVEKPPKP KRWRVDEVEQ SPKPKRRRVD EVEQSPKPKR QREAEAQQLP KPKRRRLSKL RTRHCTQAWA IRINP
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