NADH dehydrogenase [ubiquinone] 1 subunit C2…

About NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2

NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2 (NDUFC2-KCTD14) is a protein from Homo sapiens identified by UniProt accession E9PQ53, 114 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
UniProt accession	E9PQ53
Gene	NDUFC2-KCTD14
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
lysosomal storage disease · score 0.16
diastolic blood pressure · score 0.05
sex hormone-binding globulin measurement · score 0.03
aspartate aminotransferase measurement · score 0.02
brain measurement · score 0.02
body height · score 0.02
insulin like growth factor measurement · score 0.02
total cholesterol measurement · score 0.02
Stroke · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-E9PQ53-F1	alphafold	PREDICTED	84.52	—

Amino-acid sequence (114 residues)

MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR PIATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF PEEDVYCCGA ERRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2 (NDUFC2-KCTD14)