About Protein FAM227A
Protein FAM227A (FAM227A) is a protein
from Homo sapiens identified by UniProt accession
F5H4B4, 570 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Protein FAM227A |
|---|
| UniProt accession | F5H4B4 |
|---|
| Gene | FAM227A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 570 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.24
- mean corpuscular hemoglobin concentration · score 0.21
- prostate carcinoma · score 0.17
- mean corpuscular volume · score 0.16
- triglyceride measurement · score 0.14
- mathematical ability · score 0.13
- bone quantitative ultrasound measurement · score 0.12
- platelet count · score 0.12
- C-reactive protein measurement · score 0.12
- apolipoprotein A 1 measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-F5H4B4-F1 | alphafold | PREDICTED | 64.65 | — |
Amino-acid sequence (570 residues)
MNHFRKMEVI NLTTLPMIPV DEHLAVSLVA RNTMVKTVRK ELENNPPSCL IGSMHQVNQK IADINLRTEP SANSLAIERF ELEKKALREK TRSSPEDKVK RQRKSQYSCK GSELRHARSS VIKRKTADKN LLAELYQYSN FNSSKPNKLP NGVDFCDMVG NVVRAERDCL SGKHFCSGRE LEKFLSSSSP RAIWLDSFWW IFHERYQPNK ELQNNLFDRI AQHYALLLFR VPKSHSEEAL LKRLPSLLSK AVYTSFCCCF PQSWFDTHEF KSDICNTMSL WISGTYPSPQ SYDSWDYSEL DPERFRREEL MLYRRRLTKG REFSLFAGKR AFSQKPAQSR KFYHPQSSSA NSPSEKTSSA KQNSEKSLRM QNTAKEHHCQ TLVLKKPTQE VKRISEAREC ENMFPKKSCA ACKSPELTSN LFNIYGKSPL IVYFLQNYAS LQQHGKNVLI VRREKTTSTP DCTPTYTDVI SETLCSMKKR KDNLNQLYQH HWTEWNYFDK HLKELQDNFS REMKNIDPKA ADTKKANHMF IPPSAVNEES PDKKTKEGKG GEGKRRETEV EHFFPLTSKP
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