About Insulin, isoform 2
Insulin, isoform 2 (INS-IGF2) is a protein
from Homo sapiens identified by UniProt accession
F8WCM5, 200 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Insulin, isoform 2 |
|---|
| UniProt accession | F8WCM5 |
|---|
| Gene | INS-IGF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 200 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- type 1 diabetes mellitus · score 0.41
- lean body mass · score 0.39
- refractive error measurement · score 0.38
- body height · score 0.38
- type 2 diabetes mellitus · score 0.37
- appendicular lean mass · score 0.37
- BMI-adjusted hip circumference · score 0.37
- fat body mass · score 0.34
- forced expiratory volume · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-F8WCM5-F1 | alphafold | PREDICTED | 48.81 | — |
Amino-acid sequence (200 residues)
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED LQASALSLSS STSTWPEGLD ATARAPPALV VTANIGQAGG SSSRQFRQRA LGTSDSPVLF IHCPGAAGTA QGLEYRGRRV TTELVWEEVD SSPQPQGSES LPAQPPAQPA PQPEPQQARE PSPEVSCCGL WPRRPQRSQN
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