Armadillo-like helical domain-containing protein 2…

About Armadillo-like helical domain-containing protein 2

Armadillo-like helical domain-containing protein 2 (ARMH2) is a protein from Homo sapiens identified by UniProt accession H3BNL8, 230 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Armadillo-like helical domain-containing protein 2
UniProt accession	H3BNL8
Gene	ARMH2
Organism	Homo sapiens
Length	230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.19
lymphocyte percentage of leukocytes · score 0.17
neutrophil percentage of leukocytes · score 0.17
neutrophil-to-lymphocyte ratio · score 0.13
lymphocyte:monocyte ratio · score 0.09
neutrophil count · score 0.06
heel bone mineral density · score 0.04
alkaline phosphatase measurement · score 0.03
body mass index · score 0.03
non-small cell lung carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-H3BNL8-F1	alphafold	PREDICTED	89.18	—

Amino-acid sequence (230 residues)

MANSRFSCTQ IWVKMYGYFA GLCRRLQKFW RVTVKGFFVK KKEKKIPSAE TYFHEEKIVV LGQVLMNESL PIEKRAQAAQ KIGLLAFTGG PPAGNFAAEY MEEVAHLLQD EELAPKIKIL LLQSVACWCY LNPVSQKRAK SLQFIPILIS FFEGRFESTI KSETNSYLLL KFWTCYVLSV MTCNNLSCVK ELKDHSALKY HLQMLAAENW SGWTENFAEV LYFLIGFHRN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Armadillo-like helical domain-containing protein 2 (ARMH2)