Piercer of microtubule wall 2 protein (PIERCE2)

Homo sapiens — UniProt H3BRN8

Gene: PIERCE2Homo sapiensSwissProt reviewed

About Piercer of microtubule wall 2 protein

Piercer of microtubule wall 2 protein (PIERCE2) is a protein from Homo sapiens identified by UniProt accession H3BRN8, 121 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein namePiercer of microtubule wall 2 protein
UniProt accessionH3BRN8
GenePIERCE2
OrganismHomo sapiens
Length121 residues
Molecular weight—
EC numbers—
Target classUNCLASSIFIED
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (118)

Diseases linked to this target (Open Targets).

  • esophageal squamous cell carcinoma · score 0.19
  • gastric carcinoma · score 0.19
  • bile duct carcinoma · score 0.18
  • breast carcinoma · score 0.18
  • colorectal adenocarcinoma · score 0.18
  • acute myeloid leukemia · score 0.18
  • lung carcinoma · score 0.18
  • lymphoid neoplasm · score 0.18
  • esophageal adenocarcinoma · score 0.18
  • thyroid carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-H3BRN8-F1alphafoldPREDICTED74.17—

Amino-acid sequence (121 residues)

MTDRNRDKKS TSPSNSDTEM KSEQLPPCVN PGNPVFSCML DPKTLQTATS LSKPQMIMYK TNSSHYGEFL PIPQFFPCNY TPKEQVFSSH IRATGFYQNN TLNTAPDRTR TLDFPNIQHT L

Explore Piercer of microtubule wall 2 protein with MolForge

Find binders, run structure-based screening, and map this target across diseases and approved drugs with our AI-powered platform.

Browse all targets

Quick facts

UniProtH3BRN8
GenePIERCE2
OrganismHomo sapiens
Length121
Binders0
Diseases118
View on UniProt