Coiled-coil domain-containing protein 188 (CCDC188)

About Coiled-coil domain-containing protein 188

Coiled-coil domain-containing protein 188 (CCDC188) is a protein from Homo sapiens identified by UniProt accession H7C350, 402 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 188
UniProt accession	H7C350
Gene	CCDC188
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.21
sex hormone-binding globulin measurement · score 0.15
lymphatic system disease · score 0.12
pulse pressure measurement · score 0.07
eosinophil count · score 0.07
cardiovascular disease · score 0.06
body height · score 0.02
Friedreich ataxia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-H7C350-F1	alphafold	PREDICTED	60.23	—

Amino-acid sequence (402 residues)

MEGLKTLGPC GHPHPQCPPT PASSSHGGGL DQPCQGFVGW PCLGPISSAH SVQSQRPFPV PGAGGSGPTV EGEAPGLFLS SQEQRARDTE GPRQGDLEAG LGWGWPLHPG SNQGAPRQGG SIGSGTRPCP CPPLSREGGA LASPRVALSQ LQCGLLGSAE QSFLQLEQEN HSLKRQNQEL REQLGALLGP GQQFLPLCPE HSSCTALAWP PDPAGTQPLG NRAPLQLLRR ELCQGQEAFV QQSQNELQQI RLCFERKKMV ITEVWDNVAE MHMALNNQAT GLLNLKKDIR GVLDQMEDIQ LEILRERAQC RTRARKEKQM ASMSKGRPKL GSSKGLAGQL WLLTLRLLLG ALLVWTAAYV YVVNPTPFEG LVPPLLSRAT VWKLRALLDP FLRLKVDGFL PF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards