Proapoptotic nucleolar protein 1 (PANO1)

About Proapoptotic nucleolar protein 1

Proapoptotic nucleolar protein 1 (PANO1) is a protein from Homo sapiens identified by UniProt accession I0J062, 215 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Proapoptotic nucleolar protein 1
UniProt accession	I0J062
Gene	PANO1
Organism	Homo sapiens
Length	215 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neoplasm · score 0.04
keratoconus · score 0.03
Miyoshi myopathy · score 0.02
cancer · score 0.01
COVID-19 · score 0.01
triple-negative breast cancer · score 0.00
chondrosarcoma · score 0.00
in situ carcinoma · score 0.00
nervous system disease · score 0.00
Alzheimer disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-I0J062-F1	alphafold	PREDICTED	50.89	—

Amino-acid sequence (215 residues)

MGVRLRVWPA APHSISRCPR PLGAVLSILL AGGSRKGTPT ARCLGQRTKE KRVGGRSLRS EAGSGPCPTA GAQPTAPSSA WPPRLRPRTC PQMSGELPRV RPTRVGLSSL GSGPGHPPSG TRMCGERARN RRGRARRLTP EQPRIGASAG PGPPLPPARP RCSGSCHLPR PPQHLSPPQP GRVRMGAAEG SRRADTHHAR RRRRARLPAP RSAST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards