About Golgi-associated olfactory signaling regulator
Golgi-associated olfactory signaling regulator (GFY) is a protein
from Homo sapiens identified by UniProt accession
I3L273, 518 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Golgi-associated olfactory signaling regulator |
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| UniProt accession | I3L273 |
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| Gene | GFY |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- Kallmann syndrome · score 0.05
- Leber congenital amaurosis 10 · score 0.05
- Absent thumb - short stature - immunodeficiency · score 0.04
- asthma, nasal polyps, and aspirin intolerance · score 0.04
- Abnormality of the ear · score 0.04
- obstructive sleep apnea · score 0.04
- isolated congenital hypogonadotropic hypogonadism · score 0.03
- hypogonadotropic hypogonadism 5 with or without anosmia · score 0.03
- blood protein measurement · score 0.03
- atherosclerosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-I3L273-F1 | alphafold | PREDICTED | 47.49 | — |
Amino-acid sequence (518 residues)
MKSFSRILFL VFLLAGLRSK AAPSAPLPLG CGFPDMAHPS ETSPLKGASE NSKRDRLNPE FPGTPYPEPS KLPHTVSLET FPLDFTEPLN PDLRETPHPE SPETPKADSL TTSISESLDM PKTNLSKMAH PESSETPTPG PTEMPHPGSP ETPKPNFSKT SRPEFPETPN TDLMQTTPQE SPEILQLNAT EVSQAELPET SNTNPTKTPD PKSPEKHDLN STETPNSEFL QALHPDPSKT PHPESHVTHN PSPTEISQTE FPTTYYQNAT DVPRTSDPQI STSLYPETPV PFKDDATALN ELSLNPKPGT PAAIQPDSPK LPTSDSPGMV ELKAPQNSGP KESNVPPPSA RIAGPPALPG RPSQLAPATL RAPQRHSRGE GVNTIIVVER VKETGVTLVG RPRGAAGGAL CLFFAGTALL IGIFVLLWCL YRRAARQRPF AHHRLPDDGD EPVLHLDAPK DPYDLYFYAP DTWVPSHIAT KQPPPTPPLP PKLPPPPRGG RPQRLEALSP ATLPNNFV
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