About Doublecortin domain-containing protein 1
Doublecortin domain-containing protein 1 (DCDC1) is a protein
from Homo sapiens identified by UniProt accession
M0R2J8, 1783 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Doublecortin domain-containing protein 1 |
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| UniProt accession | M0R2J8 |
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| Gene | DCDC1 |
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| Organism | Homo sapiens |
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| Length | 1783 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.51
- glomerular filtration rate · score 0.43
- body height · score 0.39
- bone density · score 0.38
- diastolic blood pressure · score 0.36
- erythrocyte count · score 0.33
- heel bone mineral density · score 0.32
- sodium measurement · score 0.32
- hemoglobin measurement · score 0.31
- cortical thickness · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-M0R2J8-F1 | alphafold | PREDICTED | 68.13 | — |
Amino-acid sequence (1783 residues)
MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL NDLPREFMSS QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH QTASDHSHDE ISDLDSYKSN SKNNSCSISA SKRNRPVSAP VGQLRVAEFS SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK NGSRTVFARV TVPTITLLLE ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG EPFLNPFKKI KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS KVPLLEKCLQ NSITPLRGLL WVSKGEGFSP SGAKMYIQGV LLALYQRLKS AKKYYKQLNL VMNEQKEKIT EKVILSMTAK EHHKEQEEVS RLIDELQTAI KSNIGHLCKL GPQLQAEQEQ FSSYVYQHIK SLPANTLVPG GLQLKVFENG KNTGEISVGI SKKDLGSDSP IQTDHMMERL LLKIHQRLQG SSINPPGLNY SSMRLFDENG QEIKNPLSLK NEQKIWVSYG RAYRSPLNLA LGLTFDRVSA FARGDIMVAY KTFLDPNAVL LPGCGNWEVC EGFPINFNCT SQQIPDQFEK VDLENHFLQN KVDPNIVLHA SVSIGKWSFS GSEASSRSQI APSILWPVAS VWLITKTGMI LSRAITQGCL AIGHPIRVKA AEGTSLEGYK LILQKRHSGD DSQKWVFGTD GCIYSKAYPQ FVLTYLEELN AQVDVTQTEY HIHHGAWTTA HQEHGRNLAE EVLQESASNL GLKQLPEPSD THLMPEGSLE ETGELTVALV RKLEEKHPKA SAQRWAIKHE GTSKPGQWKH SRVENPLWNK LTYMWPVLPS GQLNEEFDWP IQGLLVPSSP PMKKPICKTT EPYAPVRLRV LQNGEKNKNR SVTILGPDIS PGRKTQCTEI LNLPSAARRL YNEKGKEIFA LKDLQRDELV YVSCGELWIN PDLSIAQQKK QIFLRNLESD IAKIQIFCST HKIEALVLEV QSDIVSGSKL AVHKPVAIFG EEKQVTEPEE KQMQEDPLTT ENASSEILDS HVRAHLRMKA CHTLPRYAWQ ETSHDFDEDD SLPKKTEKGL FENVEPQKKH SCSPKHSKLH KHCHQQFEYR DGQIISHAAP QLVLGVQGPN LRSGMEVVLV EKKSDGSHQR WIHQEDSRTF HLVSNPDLVL AVSMTKTRNE VCGYPVIVQK YKPYNNGAAN QKWHYMKNIK ALVAFHSTAL DKEITSANYA GVCTSSVIKE ENIDQPGYCY LSPDGKRKTM LCLACGQSMR TEKGLKQLLP GVPFLCISGT KTQKPFLQGP FKVISVAEVD LSCDKAEKTL SYYQARLLSL RMKTCTQAAS HSGMAATHQK AVKIIAYKNG DGYRNGKLIV AGTFPMLLTE CTEQLGLARA ASKVYTKDGT PIFTLRDLVL WALDESFLQR DSEKQKQDAA PVGKEQIIVE KNPRMKVKNR LFAKSVTSDS LDGIDKSLLT LILRNPIAIW VSCGEPFLPP NALQKAEKLE KQNWLKKDRI LADLDTMRHK MRQLKGRRVA ACQPATMVPT KSPVQPVVVE GGWTEQTQQE IKLMELIRHT EAHLSEIQEM ESKINFPIAT KRIAVKPSNL YKQPNTKRVW IYLNGGRPED GTYAWGKTIS ELLQDCSSRL KMTHPARALY TPSGEPIQSW DDIERDMVIC VSMGHGFKTP KELKQLMEIR ANYARIRRQQ GPQATDIVVS PSTKLLSLAH LHN
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