Deoxyribonuclease-2-alpha (DNASE2)

About Deoxyribonuclease-2-alpha

Deoxyribonuclease-2-alpha (DNASE2) is a protein from Homo sapiens identified by UniProt accession O00115, 360 residues long. MolForge cross-references it against 0 known binders and 185 disease associations.

Target properties

Protein name	Deoxyribonuclease-2-alpha
UniProt accession	O00115
Gene	DNASE2
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (185)

Diseases linked to this target (Open Targets).

autoinflammatory-pancytopenia syndrome due to DNASE2 deficiency · score 0.69
mean corpuscular hemoglobin · score 0.19
reticulocyte count · score 0.16
mean corpuscular volume · score 0.14
mean corpuscular hemoglobin concentration · score 0.13
erythrocyte count · score 0.13
lymphocyte percentage of leukocytes · score 0.12
body mass index · score 0.12
neutrophil percentage of leukocytes · score 0.12
systemic lupus erythematosus · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00115-F1	alphafold	PREDICTED	91.05	—

Amino-acid sequence (360 residues)

MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards