About Alkyldihydroxyacetonephosphate synthase, peroxisomal
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) is a protein
from Homo sapiens identified by UniProt accession
O00116, 658 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Alkyldihydroxyacetonephosphate synthase, peroxisomal |
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| UniProt accession | O00116 |
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| Gene | AGPS |
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| Organism | Homo sapiens |
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| Length | 658 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (181)
Diseases linked to this target (Open Targets).
- rhizomelic chondrodysplasia punctata type 3 · score 0.82
- neurodegenerative disease · score 0.45
- vital capacity · score 0.37
- alkylglycerone-phosphate synthase deficiency · score 0.37
- rhizomelic chondrodysplasia punctata · score 0.34
- refractive error · score 0.33
- forced expiratory volume · score 0.32
- testosterone measurement · score 0.21
- genetic disorder · score 0.19
- low grade glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00116-F1 | alphafold | PREDICTED | 88.42 | — |
Amino-acid sequence (658 residues)
MAEAAAAAGG TGLGAGASYG SAADRDRDPD PDRAGRRLRV LSGHLLGRPR EALSTNECKA RRAASAATAA PTATPAAQES GTIPKKRQEV MKWNGWGYND SKFIFNKKGQ IELTGKRYPL SGMGLPTFKE WIQNTLGVNV EHKTTSKASL NPSDTPPSVV NEDFLHDLKE TNISYSQEAD DRVFRAHGHC LHEIFLLREG MFERIPDIVL WPTCHDDVVK IVNLACKYNL CIIPIGGGTS VSYGLMCPAD ETRTIISLDT SQMNRILWVD ENNLTAHVEA GITGQELERQ LKESGYCTGH EPDSLEFSTV GGWVSTRASG MKKNIYGNIE DLVVHIKMVT PRGIIEKSCQ GPRMSTGPDI HHFIMGSEGT LGVITEATIK IRPVPEYQKY GSVAFPNFEQ GVACLREIAK QRCAPASIRL MDNKQFQFGH ALKPQVSSIF TSFLDGLKKF YITKFKGFDP NQLSVATLLF EGDREKVLQH EKQVYDIAAK FGGLAAGEDN GQRGYLLTYV IAYIRDLALE YYVLGESFET SAPWDRVVDL CRNVKERITR ECKEKGVQFA PFSTCRVTQT YDAGACIYFY FAFNYRGISD PLTVFEQTEA AAREEILANG GSLSHHHGVG KLRKQWLKES ISDVGFGMLK SVKEYVDPNN IFGNRNLL
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