About Kinesin-like protein KIF2A
Kinesin-like protein KIF2A (KIF2A) is a protein
from Homo sapiens identified by UniProt accession
O00139, 706 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Kinesin-like protein KIF2A |
|---|
| UniProt accession | O00139 |
|---|
| Gene | KIF2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 706 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (140)
Diseases linked to this target (Open Targets).
- Genetic central nervous system malformation · score 0.74
- mean platelet volume · score 0.45
- neurodegenerative disease · score 0.40
- platelet count · score 0.38
- diastolic blood pressure · score 0.38
- mean corpuscular volume · score 0.36
- mean corpuscular hemoglobin concentration · score 0.35
- vital capacity · score 0.35
- unipolar depression · score 0.34
- wellbeing measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00139-F1 | alphafold | PREDICTED | 78.76 | — |
Amino-acid sequence (706 residues)
MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL
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