Serine/threonine-protein kinase Sgk1 (SGK1)

About Serine/threonine-protein kinase Sgk1

Serine/threonine-protein kinase Sgk1 (SGK1) is a protein from Homo sapiens identified by UniProt accession O00141, 431 residues long. MolForge cross-references it against 0 known binders and 478 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase Sgk1
UniProt accession	O00141
Gene	SGK1
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (478)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.49
diffuse large B-cell lymphoma · score 0.49
calcium measurement · score 0.48
hair color · score 0.45
neurodegenerative disease · score 0.37
hair colour measurement · score 0.34
blood phosphate measurement · score 0.34
venous thromboembolism · score 0.33
protein measurement · score 0.33
mean corpuscular hemoglobin · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00141-F1	alphafold	PREDICTED	79.75	—

Amino-acid sequence (431 residues)

MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE EVFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD FGLCKENIEH NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK SHVFFSLINW DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK SPDSVLVTAS VKEAAEAFLG FSYAPPTDSF L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards