About Frizzled-9
Frizzled-9 (FZD9) is a protein
from Homo sapiens identified by UniProt accession
O00144, 591 residues long.
MolForge cross-references it against 0 known binders and
301 disease associations.
Target properties
| Protein name | Frizzled-9 |
|---|
| UniProt accession | O00144 |
|---|
| Gene | FZD9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 591 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (301)
Diseases linked to this target (Open Targets).
- apolipoprotein B measurement · score 0.22
- mean platelet volume · score 0.20
- protein C measurement · score 0.20
- platelet count · score 0.18
- glioblastoma multiforme · score 0.18
- testosterone measurement · score 0.12
- triglyceride measurement · score 0.11
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.09
- serum gamma-glutamyl transferase measurement · score 0.09
- protein measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00144-F1 | alphafold | PREDICTED | 80.93 | — |
Amino-acid sequence (591 residues)
MAVAPLRGAL LLWQLLAAGG AALEIGRFDP ERGRGAAPCQ AVEIPMCRGI GYNLTRMPNL LGHTSQGEAA AELAEFAPLV QYGCHSHLRF FLCSLYAPMC TDQVSTPIPA CRPMCEQARL RCAPIMEQFN FGWPDSLDCA RLPTRNDPHA LCMEAPENAT AGPAEPHKGL GMLPVAPRPA RPPGDLGPGA GGSGTCENPE KFQYVEKSRS CAPRCGPGVE VFWSRRDKDF ALVWMAVWSA LCFFSTAFTV LTFLLEPHRF QYPERPIIFL SMCYNVYSLA FLIRAVAGAQ SVACDQEAGA LYVIQEGLEN TGCTLVFLLL YYFGMASSLW WVVLTLTWFL AAGKKWGHEA IEAHGSYFHM AAWGLPALKT IVILTLRKVA GDELTGLCYV ASTDAAALTG FVLVPLSGYL VLGSSFLLTG FVALFHIRKI MKTGGTNTEK LEKLMVKIGV FSILYTVPAT CVIVCYVYER LNMDFWRLRA TEQPCAAAAG PGGRRDCSLP GGSVPTVAVF MLKIFMSLVV GITSGVWVWS SKTFQTWQSL CYRKIAAGRA RAKACRAPGS YGRGTHCHYK APTVVLHMTK TDPSLENPTH L
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