ATP-dependent RNA helicase DDX39A (DDX39A)

About ATP-dependent RNA helicase DDX39A

ATP-dependent RNA helicase DDX39A (DDX39A) is a protein from Homo sapiens identified by UniProt accession O00148, 427 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	ATP-dependent RNA helicase DDX39A
UniProt accession	O00148
Gene	DDX39A
Organism	Homo sapiens
Length	427 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.33
reticulocyte measurement · score 0.30
reticulocyte count · score 0.29
mean corpuscular hemoglobin concentration · score 0.27
mean corpuscular hemoglobin · score 0.25
Immature Reticulocyte Fraction Measurement · score 0.22
hematocrit · score 0.22
neoplasm · score 0.08
hepatocellular carcinoma · score 0.08
melanoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00148-F1	alphafold	PREDICTED	85.27	—

Amino-acid sequence (427 residues)

MAEQDVENDL LDYDEEEEPQ APQESTPAPP KKDIKGSYVS IHSSGFRDFL LKPELLRAIV DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL ATLQQIEPVN GQVTVLVMCH TRELAFQISK EYERFSKYMP SVKVSVFFGG LSIKKDEEVL KKNCPHVVVG TPGRILALVR NRSFSLKNVK HFVLDECDKM LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKDIRPVCRK FMQDPMEVFV DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVI IFVKSVQRCM ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM DIERVNIVFN YDMPEDSDTY LHRVARAGRF GTKGLAITFV SDENDAKILN DVQDRFEVNV AELPEEIDIS TYIEQSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards