PDZ and LIM domain protein 1 (PDLIM1)

About PDZ and LIM domain protein 1

PDZ and LIM domain protein 1 (PDLIM1) is a protein from Homo sapiens identified by UniProt accession O00151, 329 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	PDZ and LIM domain protein 1
UniProt accession	O00151
Gene	PDLIM1
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.39
protein measurement · score 0.37
hematocrit · score 0.37
mean platelet volume · score 0.36
leukocyte count · score 0.32
hemoglobin measurement · score 0.32
cystatin C measurement · score 0.30
monocyte count · score 0.29
platelet count · score 0.28
mean corpuscular hemoglobin concentration · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00151-F1	alphafold	PREDICTED	70.25	—

Amino-acid sequence (329 residues)

MTTQQIDLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA LANLCIGDVI TAIDGENTSN MTHLEAQNRI KGCTDNLTLT VARSEHKVWS PLVTEEGKRH PYKMNLASEP QEVLHIGSAH NRSAMPFTAS PASSTTARVI TNQYNNPAGL YSSENISNFN NALESKTAAS GVEANSRPLD HAQPPSSLVI DKESEVYKML QEKQELNEPP KQSTSFLVLQ EILESEEKGD PNKPSGFRSV KAPVTKVAAS IGNAQKLPMC DKCGTGIVGV FVKLRDRHRH PECYVCTDCG TNLKQKGHFF VEDQIYCEKH ARERVTPPEG YEVVTVFPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards