Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)

About Cytosolic acyl coenzyme A thioester hydrolase

Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) is a protein from Homo sapiens identified by UniProt accession O00154, 380 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Cytosolic acyl coenzyme A thioester hydrolase
UniProt accession	O00154
Gene	ACOT7
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

acylcarnitine measurement · score 0.27
BMI-adjusted waist circumference · score 0.22
hepatocellular carcinoma · score 0.08
cancer · score 0.08
retinoblastoma · score 0.08
non-small cell lung carcinoma · score 0.08
mean corpuscular volume · score 0.05
gonorrhea · score 0.05
lung adenocarcinoma · score 0.03
neoplasm · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00154-F1	alphafold	PREDICTED	84.70	—

Amino-acid sequence (380 residues)

MKLLARALRL CEFGRQASSR RLVAGQGCVG PRRGCCAPVQ VVGPRADLPP CGACITGRIM RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE GKGRYLQMKA KRQGHAEPQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards