About C-X-C chemokine receptor GPR25
C-X-C chemokine receptor GPR25 (GPR25) is a protein
from Homo sapiens identified by UniProt accession
O00155, 361 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | C-X-C chemokine receptor GPR25 |
|---|
| UniProt accession | O00155 |
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| Gene | GPR25 |
|---|
| Organism | Homo sapiens |
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| Length | 361 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- type 1 diabetes mellitus · score 0.12
- neuroblastoma · score 0.11
- ankylosing spondylitis · score 0.11
- Thyroid preparation use measurement · score 0.11
- hypothyroidism · score 0.10
- inflammatory bowel disease · score 0.10
- multiple sclerosis · score 0.09
- Crohn's disease · score 0.09
- myxedema · score 0.09
- ulcerative colitis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00155-F1 | alphafold | PREDICTED | 82.45 | — |
Amino-acid sequence (361 residues)
MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF AVGLLGNAFV VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA LGGRWPFGDG LCKLSSFALA GTRCAGALLL AGMSVDRYLA VVKLLEARPL RTPRCALASC CGVWAVALLA GLPSLVYRGL QPLPGGQDSQ CGEEPSHAFQ GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR NSLRIIFAIE STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR AQAANTASAS W
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