About HCLS1-associated protein X-1
HCLS1-associated protein X-1 (HAX1) is a protein
from Homo sapiens identified by UniProt accession
O00165, 279 residues long.
MolForge cross-references it against 0 known binders and
284 disease associations.
Target properties
| Protein name | HCLS1-associated protein X-1 |
|---|
| UniProt accession | O00165 |
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| Gene | HAX1 |
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| Organism | Homo sapiens |
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| Length | 279 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (284)
Diseases linked to this target (Open Targets).
- Kostmann syndrome · score 0.82
- severe congenital neutropenia · score 0.57
- constitutional neutropenia · score 0.47
- genetic disorder · score 0.41
- neutropenia · score 0.26
- mean corpuscular volume · score 0.21
- triglyceride measurement · score 0.21
- reticulocyte count · score 0.20
- mean corpuscular hemoglobin concentration · score 0.20
- mean corpuscular hemoglobin · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00165-F1 | alphafold | PREDICTED | 59.81 | — |
Amino-acid sequence (279 residues)
MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR
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